ABSTRACT
Background: the predictive roles of follicle stimulating hormone [FSH], anti-mullerian hormone [AMH] and antral follicle count [AFC] as ovarian reserve markers in women with different age groups are not established well
Objective: this study compares the value of FSH, AMH and AFC at the time of in vitro fertilization [IVF] treatment in different age groups
Materials and Methods: in this cross-sectional study, 103 women aged 20-43 years candidates for IVF/ICSI cycle were recruited. FSH, AMH and AFC on day 3 of menstrual cycle were measured. The relationship of these measured markers with outcome variables [oocytes number, number of frozen/fresh embryo and chemical and clinical pregnancy] was assessed in different age groups [i.e. 20-32, 33-37 and 38-43 years]
Results: our results show that age was correlated with clinical pregnancy, oocyte count and fresh and frozen embryo [p<0.001]. AMH, AFC and FSH were not correlated with clinical or chemical pregnancy at total population or age subgroups except the significant correlation of AFC with clinical pregnancy at 33-37 years old group. AFC was correlated with oocyte count and the number of fresh and frozen embryos in the ages group 20-32 years. In this age group, AMH was correlated with fresh and frozen embryos. AMH, AFC and FSH were correlated with oocyte count and the number of fresh embryos in age group 33-37 years. AMH was correlated with oocyte count and the number of fresh embryos in 38-43 years old group
Conclusion: we concluded that the age is the superior predictor of IVF outcome and AMH and AFC are variable predicting markers of ovarian reserve in different age groups
ABSTRACT
Objective: To evaluate the efficacy and side effects of Oxybutinin in comparison to tolterodine in treatment of overactive bladder [OAB] with detrussor overactivity [DOA] in Iranian women
Materials and Methods: One hundred Iranian old women with clinical symptoms of OAB who show IDO in the filling cystometry participated in this randomized double-blinded parallel-group by using two kinds of the drugs for 4- week course [2 mg tolterodine twice-daily, or oxybutinin 5 mg, three times a day] in alike packages. We collected data from 3-day FVC before and after the treatment course. The effectiveness of each drug was studied using the paired t-test and improvement after treatment between two groups was compared by independent T-test
Results: Positive changes in urinary urgency, Frequency and Urge incontinence after treatment in both groups were seen but mean improvements in the all were larger in the patients who treated by oxybutinin especially in terms of urgency and Urge incontinence. Dry mouth was the most common side-effect in two groups. Unlike other studies it was higher in the tolterodine group but the difference was not significant
Conclusion: Four week treatment with oxybutinin was better than tolterodine in improving urgency and urge incontinence but there were not statistically significance between them